Xiao's Google Scholar Profile

48. Wang, Y., Wang, C., Xia, M., Tian, Z., Zhou, J., Berger, J. M., Zhang, X., Xiao, H. “Engineered Small Molecule and Protein Drugs for Targeting Bone Tumors.” Molecular Therapy, 2024, DOI: 10.1016/j.ymthe.2024.03.001. [pdf]

47. Wang, Y.†, Xu, Z.†, Wu, K., Yu, L., Wang, C., Ding, H., Gao, Y., Sun, H., Wu, Y., Xia, M., Chen, Y., Xiao, H. “Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis.” Proceedings of the National Academy of Sciences (USA), 2024, DOI: 10.1073/pnas.2312929121. [pdf]

Highlighted by PNAS commentary [Link]
Featured in News Medical Life Sciences [Link],Rice News [Link],Creative Biomart Blog [Link]

46. Cheng, L.†, Wang, Y.†, Guo, Y., Zhang, S. S., Xiao, H. “Advancing Protein Therapeutics through Proximity-Induced Chemistry.” Cell Chemical Biology, 2023, DOI: 10.1016/j.chembiol.2023.09.004. [pdf]

45. Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., Ekiert, D. C., Erlandsen, B. S., Freddolino, P. L., Gilzer, D., Greening, C., Grimes, J. M., Grinter, R., Gurusaran, M., Hartmann, M. D., Hitchman, C. J., Keown, J. R., Kropp, A., Kusula, P., Lovering, A. L., Lemaitre, B., Lia, A., Liu, S., Logotheti, M., Lu, S., Markusson, S., Miller, M. D., Minasov, G., Niemann, H. H., Opazo, F., Phillips, G. N., Davies, O. R., Rommelaere, S., Rosas-Lemus, M., Roversi, P., Satchell, K., Smith, N., Wilson, M. A., Wu, K., Xia, X., Xiao, H., Zhang, W., Zhou, Z. H., Fidelis, K., Topf, M., Moult, J., Schwede, T. “Protein target highlights in CASP15: Analysis of models by structure providers.” Proteins: Structure, Function, and Bioinformatics, 2023, DOI: 10.1002/prot.26545. [pdf]

44. Yang, S., Wang, L., Loredo, A., Wang, S., Ada, N., Xiao, H. “Visible light-activated prodrug system with a novel heavy-atom-free photosensitizer.” Bioorganic & Medicinal Chemistry Letters, 2023, 91, 129365. [pdf]

43. Wang, S., Shi, H., Wang, L., Espinoza, V. B., Loredo, A., Bachilo, S. M., Tian, Z., Chen, Y., Weisman, R. B., Zhang, X., Cheng, Z., Xiao, H. “Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood–Brain Barrier for Noninvasive Brain Imaging.” Journal of the American Chemical Society, 2022, DOI: 10.1021/jacs.2c11223. [pdf]

Selected as the Cover Article for Journal of the American Chemical Society [Link]

42. Wang, L.†, Hsiung, C. H.†, Wang, S., Loredo, A., Zhang, X., Xiao, H. “Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates.” Chemical Science, 2022, DOI: 10.1039/d2sc05004h. [pdf]

41. Chen, Y., Jin, S., Zhang, M., W, K., Chang, A., Wang, S., Tian, Z., Wolynes, P. G., Xiao, H. “Unleashing the Potential of Noncanonical Amino Acid Biosynthesis for Creation of Cells with Site-Specific Tyrosine Sulfation.” Nature Communications, 2022, DOI: 10.1038/s41467-022-33111-4. [pdf]

Highlighted by NSF News [Link]
Featured in EurekAlert! [Link],Rice News [Link],ScienceDaily [Link], Genetic Engineering&Biotechnology News [Link]

40. Wu, K. L., Moore, J. A., Chen, Y., Lee, C., Xu, D., Miller, M. D., Peng, Z., Duan, Q., Philips, G. N., Uribe, R. A., Xiao, H. “Expanding the Eukaryotic Genetic Code with a Biosynthesized 21st Amino Acid.” Protein Science, 2022, DOI: 10.1002/PRO.4443. [pdf]

39. Tian, Z.†, Yu, C.†, Zhang, W., Wu, K. L., Wang, C., Gupta, R., Zhan, X., Ling, W., Chen, Y., Zhang, X., Xiao, H. “Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone.” ACS Central Science, 2022, DOI: 10.1021/acscentsci.1c01024. [pdf]

Featured in EurekAlert! [Link],Rice News [Link],ScienceDaily [Link], TechnologyNetworks [Link]

Selected as the Front Cover for ACS Central Science [Link]

38.Chen, Y., Loredo, A., Chang, A., Zhang, M., Liu, R., Xiao, H. “Biosynthesis and Genetic Incorporation of L-3,4-Dihydroxyphenylalanine into Proteins.” Journal of Molecular Biology, 2021, DOI: 10.1016/j.jmb.2021.167412. [pdf]

37.Cameron, T., Vega, D., Yu, C., Xiao, H., Margolin, W. “ZipA uses a two-pronged FtsZ-binding mechanism necessary for cell division.” mBio, 2021, DOI: 10.1128/mbio.02529-21. [pdf]

36. Wang, L.†, Wang, S.†, Tang, J., Espinoza, V. B, Loredo, A., Tian, Z., Weisman, R. B., Xiao, H. “Oxime as a General Photocage for the Design of Visible Light Photoactivatable Fluorophores.” Chemical Science, 2021, DOI: 10.1039/D1SC05351E. [pdf]

35. Adeniji, O. S., Kuri-Cervantes, L., Yu, C., Xu, Z., Ho, M., Chew, G. M., Shikuma, C., Tomescu, C., George, A. F., Roan, N. R., Ndhlovu, L. C., Muthumani, K., Weiner, D. B., Xiao, H., Abdel-Mohsen, M. “Siglec-9 Defines and Restrains a Natural Killer Subpopulation Highly Cytotoxic to HIV-infected Cells.” PLOS Pathogens, 2021, DOI: 10.1371/journal.ppat.1010034. [pdf]

34. Cao, Y. J., Yu, C., Wu, K. L., Wang, X., Liu, D., Tian, Z., Zhao, L., Qi, X., Loredo, A., Chung, A., Xiao, H. “Synthesis of precision antibody conjugates using proximity-induced chemistry.” Theranostics, 2021, 11, 9107. [pdf]

33. Wu, K. L., Yu, C., Lee, C., Zuo, C., Ball, Z. T., Zhang, X., Xiao, H. “Precision Modification of Native Antibodies.” Bioconjugate Chemistry, 2021, DOI: 10.1021/acs.bioconjchem.1c00342. [pdf]

32. Tian, Z., Ling, W., Yu, C., Chen, Y., Xu, Z., Bado, I., Loredo, A., Wang, L., Wang, H., Wu, K. L., Zhang, W., Zhang, X., Xiao, H. “Harness the Power of the Antibody to Fight Bone Metastasis.” Science Advances, 2021, DOI: 10.1126/sciadv.abf2051. [pdf]

Featured in The Scientist [Link],Rice News [Link],ScienceDaily [Link], TechnologyNetworks [Link]

31. Ortiz-Rodríguez, L. A., Hoehn, S., Loredo, A., Wang, L., Xiao, H., Crespo-Hernández, C. E. “Electronic Relaxation Pathways in Heavy-Atom-Free Photosensitizers Absorbing Near-Infrared Radiation and Exhibiting High Yields of Singlet Oxygen Generation.” Journal of the American Chemical Society, 2021, DOI: 10.1021/jacs.0c13203. [pdf]

30. Loredo, A., Wang, L., Shichao, W., Xiao, H. “Single-Atom Switching as a General Approach to Designing Colorimetric and Fluorogenic Probes for Mercury Ions.” Dyes and Pigments, 2021, 186, 109014. [pdf]

29. Chen, Y., Tang, J., Wang, L. S., Tian, Z., Cardenas, A., Fang, X., Chatterjee, A., Xiao, H. “Creation of Bacterial Cells with 5-Hydroxytryptophan as a 21st Amino Acid Building Block.” Chem, 2020, 6, 1-11. [pdf]

Highlighted by Nature Chemical Biology [Link].
Featured in Rice News [Link],RiceTMC News [Link],EurekAlert! [Link] ,ScienceDaily [Link].

28. Tang, J.†, Wang, L. S.†, Loredo, A., Cole, C., Xiao, H. “Single-Atom Replacement as a General Approach Towards Visible-Light/Near-Infrared Heavy-Atom-Free Photosensitizers for Photodynamic Therapy.” Chemical Science, 2020, DOI: 10.1039/D0SC02286A. [pdf]

27. Tang, J.†, Yu, C.†, Loredo, A., Chen, Y., Xiao, H. “VIP: Site‐Specific Incorporation of a Photoactivatable Fluorescent Amino Acid.” ChemBioChem, 2020, DOI: 10.1002/cbic.202000602. [pdf]

26. Loredo, A.†, Tang, J.†, Wang, L. S., Wu, K. L., Peng, Z., Xiao, H. “Tetrazine as a General Phototrigger to Turn on Fluorophores.” Chemical Science, 2020, DOI: 10.1039/D0SC01009J. [pdf]

Featured in ChemistryViews [Link]

25. Gray, M. A., Stanczak, M. A., Mantuano, N. R., Xiao, H., Pijnenborg, J. F. A., Malaker, S. A., Weidenbacher, P.A., Miller, C. L., Tanzo, J. T., Ahn, G., Woods, E. C., Läubli, H., Bertozzi, C. “Targeted glycan degradation potentiates the anticancer immune response in vivo.” Nature Chemical Biology, 2020, DOI: 10.1038/s41589-020-0622-x. [pdf]

24. Chen, Y.†, Wu, K. L.†, Pei, J., Tang, J., Loredo, A., Peng, Z., Gupta, R., Xiao, H. “Addition of Isocyanide-containing Amino Acids to the Genetic Code for Protein Labeling and Activation.” ACS Chemical Biology, 2019, DOI: 10.1021/acschembio.9b00678. [pdf]

23. Stanford, M. G., Li, J., Chen, Y., McHugh, E. A., Liopo, A., Xiao, H., Tour, J. M. “Self-Sterilizing Laser-Induced Graphene Bacterial Air Filter.” ACS Nano, 2019, DOI: 10.1021/acsnano.9b05983. [pdf]

22. Tang, J.†, Robichaux, M.†, Wu, K. L., Nguyen, T. N., Zhou, Y., Wensel, T. G., Xiao, H. “Single-Atom Fluorescence Switch: A General Approach towards Visible Light-Activated Dyes for Biological Imaging.” Journal of the American Chemical Society, 2019, 141, 37, 14699. [pdf]

Highlighted by JACS Spotlight [Link], and C&EN [Link].
Featured in Rice News [Link], TMC NEWS [Link], FUTURITY [Link], EurekAlert! [Link], ScienceDaily [Link].

21. Yu, C.†, Tang, J.†, Loredo, A., Chen, Y., Jung, S. Y., Jain, A., Gordon, A., Xiao, H. “Proximity-Induced Site-Specific Antibody Conjugation.” Bioconjugate Chemistry, 2018, 29, 11, 3522. (†contributed equally) [pdf]

Featured in Rice News [Link], Medical Express [Link], TMC NEWS [Link], Laboratory Equipment [Link], TECHNOLOGY NETWORKS [Link], CNU [Link], BIONITY@Germany [Link], News Archives UK [Link], FUTURITY [Link], EurekAlert! [Link], R&D [Link].

20. Chen, Y., Loredo, A., Gordon, A., Tang, J., Yu, C., Ordonez, J., Xiao, H. “A noncanonical amino acid-based relay system for site-specific protein labeling.” Chemical Communications, 2018, 54, 7187. [pdf]

Prior to Rice University:

19. Xuan, W., Collins, D., Koh, M., Shao, S., Yao, A., Xiao, H., Garner, P., Schultz, P. G. “Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins.” ACS Chemical Biology 2018, 13, 578-581. [pdf]

18. Xiao, H.†, Woods, E. C.†, Vukojicic, P., Bertozzi, C. R. “Precision Glycocalyx Editing as a Strategy for Cancer Immunotherapy.” Proceedings of the National Academy of Sciences (USA) 2016, 113, 10304-10309. [pdf]

Highlighted by Science Translational Medicine, Sci. Transl. Med., [Link]; PNAS Commentary, Proc. Natl. Acad. Sci. (USA), [Link]; ACS Chemical Biology, ACS Chem. Biol., [Link]
Featured in Stanford News, Next Big Future, MedicalXpress and etc. [Link]

17. Xiao, H., Schultz, P. G. “At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code.” Cold Spring Harbor Perspectives in Biology, 2016, 8, a023945. [pdf]

16. Liu, T., Wang, Y., Luo, X. Z., Li, J., Reed, S. A., Xiao, H., Young, T. S., Schultz, P. G. “Enhancing Protein Stability with Extended Disulfide Bonds.” Proceedings of the National Academy of Sciences (USA), 2016, 113, 5910-5915. [pdf]

15. Cao,Y., Rodgers, D. T., Du, J., Ahmad, I., Hampton, E. N., Ma, J. S., Mazagova, M., Choi, S. H., Yun, H. Y., Xiao, H., Yang, P., Luo, X., Lim, R. K., Pugh, H. M., Wang, F., Kazane, S. A., Wright, T. M., Kim, C. H., Schultz, P. G., Young, T. S. “Design of Switchable Chimeric Antigen Receptor T cells Targeting Breast Cancer.” Angewandte Chemie International Edition, 2016, 55, 7520-7524. [pdf]

14. Xiao, H.†, Nasertorabi, F.†, Choi, S. H., Han, G. W., Reed, S. A., Stevens, R. C., Schultz, P. G. “Exploring the Potential Impact of an Expanded Genetic Code on Protein Function.” Proceedings of the National Academy of Sciences (USA), 2015, 112(22), 6961-6966. († contributed equally) [pdf]

Featured in The San Diego Union-Tribune. [Link]

13. Xiao, H.†, Xuan, W.†, Shao, S., Liu, T., Schultz, P. G. “Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones.” ACS Chemical Biology, 2015, 10, 1599-1603. († contributed equally) [pdf]

12. Chatterjee, A.†, Lajoie, M. J.†, Xiao, H.†, Church, G. M., Schultz, P. G. “A Bacterial Strain with a Unique Quadruplet Codon Specifying Nonnative Amino Acids.” ChembioChem, 2014, 15(12), 1782-1786. († contributed equally) [pdf]

11. Xiao, H.†, Peters, F. B.†, Yang, P. Y., Reed, S., Chittuluru, J. R., Schultz, P. G. “Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNA Synthetase.” ACS Chemical Biology, 2014, 9, 1092-1096. († contributed equally) [pdf]

10. Xiao, H.†, Chatterjee, A.†, Choi, S. H., Bajjuri, K. M., Sinha, S. C., Schultz, P. G. “Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells.” Angewandte Chemie International Edition, 2013, 52(52), 14080-14083. († contributed equally) [pdf]

9. Chatterjee, A.†, Xiao, H.†, Bollong, M., Ai, H. W., Schultz, P. G. “Efficient Viral Delivery System for Unnatural Amino Acid Mutagenesis in Mammalian Cells.” Proceedings of the National Academy of Sciences (USA), 2013, 110(29), 11803-11808. († contributed equally) [pdf]

8. Chatterjee, A.†, Xiao, H.†, Yang, P. Y., Soundararajan, G., Schultz, P. G. “A Tryptophanyl-tRNA Synthetase/tRNA Pair for Unnatural Amino Acid Mutagenesis in E. coli .” Angewandte Chemie International Edition , 2013, 52(19), 5106-5109. († contributed equally) [pdf]

7. Chatterjee, A.†, Xiao, H.†, Schultz, P. G. “Evolution of Multiple, Mutually Orthogonal Prolyl-tRNA Synthetase/tRNA Pairs for Unnatural Amino Acid Mutagenesis in Escherichia coli.” Proceedings of the National Academy of Sciences (USA), 2012, 109(37), 14841-14846. († contributed equally) [pdf]

6. Chatterjee, A., Sun, S. B., Furman, J. L., Xiao, H., Schultz, P. G. “A Versatile Platform for Single- and Multiple-Unnatural Amino Acid Mutagenesis in Escherichia coli.” Biochemistry, 2013, 52(10), 1828-1837. [pdf]

5. Mei, T. S., Leow, D. S., Xiao, H., Laforteza, B. N., Yu, J. Q. “Synthesis of Indolines via Pd(II)-Catalyzed Amination of C-H Bonds Using PhI(OAc)2 as the Bystanding Oxidant.” Organic Letters, 2013, 15(12), 3058-3061. [pdf]

4. Han, Z. Y., Guo, R., Wang, P. S., Chen, D. F., Xiao, H., Gong, L. Z. “Enantioselective Concomitant Creation of Vicinal Quaternary Stereogenic Centers via Cyclization of Alkynols Triggered Addition of Azlactones.” Tetrahedron Letters, 2011, 52(45), 5963-5967. [pdf]

3. Han, Z. Y., Xiao, H., Gong, L. Z. “Consecutive Intramolecular Hydroamination/Asymmetric Transfer Hydrogenation under Relay Catalysis of an Achiral Gold Complex/Chiral Brønsted Acid Binary System.” Journal of the American Chemical Society, 2009, 131(26), 9182-9183. [pdf]

2. Han, Z. Y., Xiao, H., Gong, L. Z. “Dynamic Kinetic Asymmetric Transfer Hydrogenation of Racemic 2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines Catalyzed by Chiral Phosphoric Acids.” Bioorganic & Medicinal Chemistry Letters, 2009, 19(14), 3729-3732. [pdf]

1. Chen, X. H., Wei, Q., Luo, S. W., Xiao, H., Gong, L. Z. “Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity.” Journal of the American Chemical Society, 2009, 131(38), 13819-13825. [pdf]