43. Wang, S., Shi, H., Wang, L., Espinoza, V. B., Loredo, A., Bachilo, S. M., Tian, Z., Chen, Y., Weisman, R. B., Zhang, X., Cheng, Z., Xiao, H. “Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood–Brain Barrier for Noninvasive Brain Imaging.” Journal of the American Chemical Society, 2022, DOI: 10.1021/jacs.2c11223. [pdf]

Selected as the Cover Article for Journal of the American Chemical Society [Link]

42. Wang, L.†, Hsiung, C. H.†, Wang, S., Loredo, A., Zhang, X., Xiao, H. “Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates.” Chemical Science, 2022, DOI: 10.1039/d2sc05004h. [pdf]

41. Chen, Y., Jin, S., Zhang, M., W, K., Chang, A., Wang, S., Tian, Z., Wolynes, P. G., Xiao, H. “Unleashing the Potential of Noncanonical Amino Acid Biosynthesis for Creation of Cells with Site-Specific Tyrosine Sulfation.” Nature Communications, 2022, DOI: 10.1038/s41467-022-33111-4. [pdf]

Highlighted by NSF News [Link]
Featured in EurekAlert! [Link],Rice News [Link],ScienceDaily [Link], Genetic Engineering&Biotechnology News [Link]

40. Wu, K. L., Moore, J. A., Chen, Y., Lee, C., Xu, D., Miller, M. D., Peng, Z., Duan, Q., Philips, G. N., Uribe, R. A., Xiao, H. “Expanding the Eukaryotic Genetic Code with a Biosynthesized 21st Amino Acid.” Protein Science, 2022, DOI: 10.1002/PRO.4443. [pdf]

39. Tian, Z.†, Yu, C.†, Zhang, W., Wu, K. L., Wang, C., Gupta, R., Zhan, X., Ling, W., Chen, Y., Zhang, X., Xiao, H. “Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone.” ACS Central Science, 2022, DOI: 10.1021/acscentsci.1c01024. [pdf]

Featured in EurekAlert! [Link],Rice News [Link],ScienceDaily [Link], TechnologyNetworks [Link]

Selected as the Front Cover for ACS Central Science [Link]

38.Chen, Y., Loredo, A., Chang, A., Zhang, M., Liu, R., Xiao, H. “Biosynthesis and Genetic Incorporation of L-3,4-Dihydroxyphenylalanine into Proteins.” Journal of Molecular Biology, 2021, DOI: 10.1016/j.jmb.2021.167412. [pdf]

37.Cameron, T., Vega, D., Yu, C., Xiao, H., Margolin, W. “ZipA uses a two-pronged FtsZ-binding mechanism necessary for cell division.” mBio, 2021, DOI: 10.1128/mbio.02529-21. [pdf]

36. Wang, L.†, Wang, S.†, Tang, J., Espinoza, V. B, Loredo, A., Tian, Z., Weisman, R. B., Xiao, H. “Oxime as a General Photocage for the Design of Visible Light Photoactivatable Fluorophores.” Chemical Science, 2021, DOI: 10.1039/D1SC05351E. [pdf]

35. Adeniji, O. S., Kuri-Cervantes, L., Yu, C., Xu, Z., Ho, M., Chew, G. M., Shikuma, C., Tomescu, C., George, A. F., Roan, N. R., Ndhlovu, L. C., Muthumani, K., Weiner, D. B., Xiao, H., Abdel-Mohsen, M. “Siglec-9 Defines and Restrains a Natural Killer Subpopulation Highly Cytotoxic to HIV-infected Cells.” PLOS Pathogens, 2021, DOI: 10.1371/journal.ppat.1010034. [pdf]

34. Cao, Y. J., Yu, C., Wu, K. L., Wang, X., Liu, D., Tian, Z., Zhao, L., Qi, X., Loredo, A., Chung, A., Xiao, H. “Synthesis of precision antibody conjugates using proximity-induced chemistry.” Theranostics, 2021, 11, 9107. [pdf]

33. Wu, K. L., Yu, C., Lee, C., Zuo, C., Ball, Z. T., Zhang, X., Xiao, H. “Precision Modification of Native Antibodies.” Bioconjugate Chemistry, 2021, DOI: 10.1021/acs.bioconjchem.1c00342. [pdf]

32. Tian, Z., Ling, W., Yu, C., Chen, Y., Xu, Z., Bado, I., Loredo, A., Wang, L., Wang, H., Wu, K. L., Zhang, W., Zhang, X., Xiao, H. “Harness the Power of the Antibody to Fight Bone Metastasis.” Science Advances, 2021, DOI: 10.1126/sciadv.abf2051. [pdf]

Featured in The Scientist [Link],Rice News [Link],ScienceDaily [Link], TechnologyNetworks [Link]

31. Ortiz-Rodríguez, L. A., Hoehn, S., Loredo, A., Wang, L., Xiao, H., Crespo-Hernández, C. E. “Electronic Relaxation Pathways in Heavy-Atom-Free Photosensitizers Absorbing Near-Infrared Radiation and Exhibiting High Yields of Singlet Oxygen Generation.” Journal of the American Chemical Society, 2021, DOI: 10.1021/jacs.0c13203. [pdf]

30. Loredo, A., Wang, L., Shichao, W., Xiao, H. “Single-Atom Switching as a General Approach to Designing Colorimetric and Fluorogenic Probes for Mercury Ions.” Dyes and Pigments, 2021, 186, 109014. [pdf]

29. Chen, Y., Tang, J., Wang, L. S., Tian, Z., Cardenas, A., Fang, X., Chatterjee, A., Xiao, H. “Creation of Bacterial Cells with 5-Hydroxytryptophan as a 21st Amino Acid Building Block.” Chem, 2020, 6, 1-11. [pdf]

Highlighted by Nature Chemical Biology [Link].
Featured in Rice News [Link],RiceTMC News [Link],EurekAlert! [Link] ,ScienceDaily [Link].

28. Tang, J.†, Wang, L. S.†, Loredo, A., Cole, C., Xiao, H. “Single-Atom Replacement as a General Approach Towards Visible-Light/Near-Infrared Heavy-Atom-Free Photosensitizers for Photodynamic Therapy.” Chemical Science, 2020, DOI: 10.1039/D0SC02286A. [pdf]

27. Tang, J.†, Yu, C.†, Loredo, A., Chen, Y., Xiao, H. “VIP: Site‐Specific Incorporation of a Photoactivatable Fluorescent Amino Acid.” ChemBioChem, 2020, DOI: 10.1002/cbic.202000602. [pdf]

26. Loredo, A.†, Tang, J.†, Wang, L. S., Wu, K. L., Peng, Z., Xiao, H. “Tetrazine as a General Phototrigger to Turn on Fluorophores.” Chemical Science, 2020, DOI: 10.1039/D0SC01009J. [pdf]

Featured in ChemistryViews [Link]

25. Gray, M. A., Stanczak, M. A., Mantuano, N. R., Xiao, H., Pijnenborg, J. F. A., Malaker, S. A., Weidenbacher, P.A., Miller, C. L., Tanzo, J. T., Ahn, G., Woods, E. C., Läubli, H., Bertozzi, C. “Targeted glycan degradation potentiates the anticancer immune response in vivo.” Nature Chemical Biology, 2020, DOI: 10.1038/s41589-020-0622-x. [pdf]

24. Chen, Y.†, Wu, K. L.†, Pei, J., Tang, J., Loredo, A., Peng, Z., Gupta, R., Xiao, H. “Addition of Isocyanide-containing Amino Acids to the Genetic Code for Protein Labeling and Activation.” ACS Chemical Biology, 2019, DOI: 10.1021/acschembio.9b00678. [pdf]

23. Stanford, M. G., Li, J., Chen, Y., McHugh, E. A., Liopo, A., Xiao, H., Tour, J. M. “Self-Sterilizing Laser-Induced Graphene Bacterial Air Filter.” ACS Nano, 2019, DOI: 10.1021/acsnano.9b05983. [pdf]

22. Tang, J.†, Robichaux, M.†, Wu, K. L., Nguyen, T. N., Zhou, Y., Wensel, T. G., Xiao, H. “Single-Atom Fluorescence Switch: A General Approach towards Visible Light-Activated Dyes for Biological Imaging.” Journal of the American Chemical Society, 2019, 141, 37, 14699. [pdf]

Highlighted by JACS Spotlight [Link], and C&EN [Link].
Featured in Rice News [Link], TMC NEWS [Link], FUTURITY [Link], EurekAlert! [Link], ScienceDaily [Link].

21. Yu, C.†, Tang, J.†, Loredo, A., Chen, Y., Jung, S. Y., Jain, A., Gordon, A., Xiao, H. “Proximity-Induced Site-Specific Antibody Conjugation.” Bioconjugate Chemistry, 2018, 29, 11, 3522. (†contributed equally) [pdf]

Featured in Rice News [Link], Medical Express [Link], TMC NEWS [Link], Laboratory Equipment [Link], TECHNOLOGY NETWORKS [Link], CNU [Link], BIONITY@Germany [Link], News Archives UK [Link], FUTURITY [Link], EurekAlert! [Link], R&D [Link].

20. Chen, Y., Loredo, A., Gordon, A., Tang, J., Yu, C., Ordonez, J., Xiao, H. “A noncanonical amino acid-based relay system for site-specific protein labeling.” Chemical Communications, 2018, 54, 7187. [pdf]

Prior to Rice University:

19. Xuan, W., Collins, D., Koh, M., Shao, S., Yao, A., Xiao, H., Garner, P., Schultz, P. G. “Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins.” ACS Chemical Biology 2018, 13, 578-581. [pdf]

18. Xiao, H.†, Woods, E. C.†, Vukojicic, P., Bertozzi, C. R. “Precision Glycocalyx Editing as a Strategy for Cancer Immunotherapy.” Proceedings of the National Academy of Sciences (USA) 2016, 113, 10304-10309. [pdf]

Highlighted by Science Translational Medicine, Sci. Transl. Med., [Link]; PNAS Commentary, Proc. Natl. Acad. Sci. (USA), [Link]; ACS Chemical Biology, ACS Chem. Biol., [Link]
Featured in Stanford News, Next Big Future, MedicalXpress and etc. [Link]

17. Xiao, H., Schultz, P. G. “At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code.” Cold Spring Harbor Perspectives in Biology, 2016, 8, a023945. [pdf]

16. Liu, T., Wang, Y., Luo, X. Z., Li, J., Reed, S. A., Xiao, H., Young, T. S., Schultz, P. G. “Enhancing Protein Stability with Extended Disulfide Bonds.” Proceedings of the National Academy of Sciences (USA), 2016, 113, 5910-5915. [pdf]

15. Cao,Y., Rodgers, D. T., Du, J., Ahmad, I., Hampton, E. N., Ma, J. S., Mazagova, M., Choi, S. H., Yun, H. Y., Xiao, H., Yang, P., Luo, X., Lim, R. K., Pugh, H. M., Wang, F., Kazane, S. A., Wright, T. M., Kim, C. H., Schultz, P. G., Young, T. S. “Design of Switchable Chimeric Antigen Receptor T cells Targeting Breast Cancer.” Angewandte Chemie International Edition, 2016, 55, 7520-7524. [pdf]

14. Xiao, H.†, Nasertorabi, F.†, Choi, S. H., Han, G. W., Reed, S. A., Stevens, R. C., Schultz, P. G. “Exploring the Potential Impact of an Expanded Genetic Code on Protein Function.” Proceedings of the National Academy of Sciences (USA), 2015, 112(22), 6961-6966. († contributed equally) [pdf]

Featured in The San Diego Union-Tribune. [Link]

13. Xiao, H.†, Xuan, W.†, Shao, S., Liu, T., Schultz, P. G. “Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones.” ACS Chemical Biology, 2015, 10, 1599-1603. († contributed equally) [pdf]

12. Chatterjee, A.†, Lajoie, M. J.†, Xiao, H.†, Church, G. M., Schultz, P. G. “A Bacterial Strain with a Unique Quadruplet Codon Specifying Nonnative Amino Acids.” ChembioChem, 2014, 15(12), 1782-1786. († contributed equally) [pdf]

11. Xiao, H.†, Peters, F. B.†, Yang, P. Y., Reed, S., Chittuluru, J. R., Schultz, P. G. “Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNA Synthetase.” ACS Chemical Biology, 2014, 9, 1092-1096. († contributed equally) [pdf]

10. Xiao, H.†, Chatterjee, A.†, Choi, S. H., Bajjuri, K. M., Sinha, S. C., Schultz, P. G. “Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells.” Angewandte Chemie International Edition, 2013, 52(52), 14080-14083. († contributed equally) [pdf]

9. Chatterjee, A.†, Xiao, H.†, Bollong, M., Ai, H. W., Schultz, P. G. “Efficient Viral Delivery System for Unnatural Amino Acid Mutagenesis in Mammalian Cells.” Proceedings of the National Academy of Sciences (USA), 2013, 110(29), 11803-11808. († contributed equally) [pdf]

8. Chatterjee, A.†, Xiao, H.†, Yang, P. Y., Soundararajan, G., Schultz, P. G. “A Tryptophanyl-tRNA Synthetase/tRNA Pair for Unnatural Amino Acid Mutagenesis in E. coli .” Angewandte Chemie International Edition , 2013, 52(19), 5106-5109. († contributed equally) [pdf]

7. Chatterjee, A.†, Xiao, H.†, Schultz, P. G. “Evolution of Multiple, Mutually Orthogonal Prolyl-tRNA Synthetase/tRNA Pairs for Unnatural Amino Acid Mutagenesis in Escherichia coli.” Proceedings of the National Academy of Sciences (USA), 2012, 109(37), 14841-14846. († contributed equally) [pdf]

6. Chatterjee, A., Sun, S. B., Furman, J. L., Xiao, H., Schultz, P. G. “A Versatile Platform for Single- and Multiple-Unnatural Amino Acid Mutagenesis in Escherichia coli.” Biochemistry, 2013, 52(10), 1828-1837. [pdf]

5. Mei, T. S., Leow, D. S., Xiao, H., Laforteza, B. N., Yu, J. Q. “Synthesis of Indolines via Pd(II)-Catalyzed Amination of C-H Bonds Using PhI(OAc)2 as the Bystanding Oxidant.” Organic Letters, 2013, 15(12), 3058-3061. [pdf]

4. Han, Z. Y., Guo, R., Wang, P. S., Chen, D. F., Xiao, H., Gong, L. Z. “Enantioselective Concomitant Creation of Vicinal Quaternary Stereogenic Centers via Cyclization of Alkynols Triggered Addition of Azlactones.” Tetrahedron Letters, 2011, 52(45), 5963-5967. [pdf]

3. Han, Z. Y., Xiao, H., Gong, L. Z. “Consecutive Intramolecular Hydroamination/Asymmetric Transfer Hydrogenation under Relay Catalysis of an Achiral Gold Complex/Chiral Brønsted Acid Binary System.” Journal of the American Chemical Society, 2009, 131(26), 9182-9183. [pdf]

2. Han, Z. Y., Xiao, H., Gong, L. Z. “Dynamic Kinetic Asymmetric Transfer Hydrogenation of Racemic 2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines Catalyzed by Chiral Phosphoric Acids.” Bioorganic & Medicinal Chemistry Letters, 2009, 19(14), 3729-3732. [pdf]

1. Chen, X. H., Wei, Q., Luo, S. W., Xiao, H., Gong, L. Z. “Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity.” Journal of the American Chemical Society, 2009, 131(38), 13819-13825. [pdf]